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Assay Detail

CHEMBL762988

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides.
Wiesner J, Mitsch A, Wissner P, Krämer O, Jomaa H, Schlitzer M.
Bioorg Med Chem Lett (2002) 12 : 2681 -2683
PubMed 12217353 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.51 7.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67122 1 7.12
CHEMBL92540 1 7.08
CHEMBL327196 1 7.07
CHEMBL91087 1 7.06
CHEMBL328130 1 6.92
CHEMBL329401 1 6.90
CHEMBL88687 1 6.89
CHEMBL90987 1 6.84
CHEMBL76 CHLOROQUINE 4.0 1 6.77
CHEMBL88380 1 6.70
CHEMBL131946 1 6.68
CHEMBL330705 1 6.52
CHEMBL90495 1 6.52
CHEMBL330123 1 6.50
CHEMBL90812 1 6.47
CHEMBL170 QUININE 4.0 1 6.42
CHEMBL91248 1 6.38
CHEMBL314713 1 6.23
CHEMBL327475 1 6.17
CHEMBL89599 1 6.12
CHEMBL91215 1 6.00
CHEMBL747 CYCLOGUANIL 2.0 1 5.66
CHEMBL36 PYRIMETHAMINE 4.0 1 5.60
CHEMBL91489 1 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67122 IC50 = 75.0 nM 7.12
CHEMBL92540 IC50 = 84.0 nM 7.08
CHEMBL327196 IC50 = 85.0 nM 7.07
CHEMBL91087 IC50 = 88.0 nM 7.06
CHEMBL328130 IC50 = 120.0 nM 6.92
CHEMBL329401 IC50 = 125.0 nM 6.90
CHEMBL88687 IC50 = 130.0 nM 6.89
CHEMBL90987 IC50 = 145.0 nM 6.84
CHEMBL76 CHLOROQUINE IC50 = 170.0 nM 6.77
CHEMBL88380 IC50 = 200.0 nM 6.70
CHEMBL131946 IC50 = 210.0 nM 6.68
CHEMBL330705 IC50 = 300.0 nM 6.52
CHEMBL90495 IC50 = 300.0 nM 6.52
CHEMBL330123 IC50 = 320.0 nM 6.50
CHEMBL90812 IC50 = 340.0 nM 6.47
CHEMBL170 QUININE IC50 = 380.0 nM 6.42
CHEMBL91248 IC50 = 415.0 nM 6.38
CHEMBL314713 IC50 = 590.0 nM 6.23
CHEMBL327475 IC50 = 670.0 nM 6.17
CHEMBL89599 IC50 = 750.0 nM 6.12
CHEMBL91215 IC50 = 1000.0 nM 6.00
CHEMBL747 CYCLOGUANIL IC50 = 2200.0 nM 5.66
CHEMBL36 PYRIMETHAMINE IC50 = 2500.0 nM 5.60
CHEMBL91489 IC50 = 2700.0 nM 5.57