Assay Detail
Functional
CHEMBL762989
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Inhibitory concentration IC50 against Plasmodium falciparum K1 by [3H]hypoxanthine uptake over 24 hr
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.69 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.57 |
| CHEMBL35072 | — | — | 1 | 7.85 |
| CHEMBL37940 | — | — | 1 | 7.70 |
| CHEMBL416958 | — | — | 1 | 7.60 |
| CHEMBL35745 | — | — | 1 | 7.52 |
| CHEMBL37647 | — | — | 1 | 7.52 |
| CHEMBL37404 | — | — | 1 | 7.47 |
| CHEMBL34804 | — | — | 1 | 7.40 |
| CHEMBL35917 | — | — | 1 | 7.40 |
| CHEMBL37492 | — | — | 1 | 7.30 |
| CHEMBL289040 | — | — | 1 | 7.22 |
| CHEMBL36828 | — | — | 1 | 7.16 |
| CHEMBL35422 | — | — | 1 | 7.00 |
| CHEMBL290443 | — | — | 1 | 7.00 |
| CHEMBL38217 | — | — | 1 | 6.82 |
| CHEMBL35439 | — | — | 1 | 6.82 |
| CHEMBL290441 | — | — | 1 | 6.82 |
| CHEMBL289684 | — | — | 1 | 6.80 |
| CHEMBL287878 | — | — | 1 | 6.80 |
| CHEMBL290766 | — | — | 1 | 6.70 |
| CHEMBL290767 | — | — | 1 | 6.70 |
| CHEMBL37787 | — | — | 1 | 6.60 |
| CHEMBL36404 | — | — | 1 | 6.60 |
| CHEMBL34930 | — | — | 1 | 6.54 |
| CHEMBL288290 | — | — | 1 | 6.52 |
| CHEMBL34843 | — | — | 1 | 6.50 |
| CHEMBL415467 | — | — | 1 | 6.40 |
| CHEMBL37615 | — | — | 1 | 6.40 |
| CHEMBL34941 | — | — | 1 | 6.33 |
| CHEMBL35205 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL35072 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL37940 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL416958 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL35745 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL37647 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL37404 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL34804 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL35917 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL37492 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL289040 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL36828 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL35422 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL290443 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL290441 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL38217 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL35439 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL289684 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL287878 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL290766 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL290767 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL37787 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL36404 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL34930 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL288290 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL34843 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL415467 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL37615 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL34941 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL35205 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL35588 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL38374 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL43 | AMSACRINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL290585 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL289352 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL37644 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL34598 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL9657 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL9806 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL287889 | o-Amsacrine | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL36532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL36405 | — | IC50 | > | 10000.0 | nM | - |