Assay Detail
Functional
CHEMBL762990
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Concentration required to reduce chloroquine IC50 by 50%
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.67 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321034 | — | — | 1 | 6.70 |
| CHEMBL321238 | — | — | 2 | 6.60 |
| CHEMBL108992 | — | — | 1 | 6.52 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 1 | 6.40 |
| CHEMBL324180 | — | — | 1 | 6.40 |
| CHEMBL321924 | — | — | 1 | 6.30 |
| CHEMBL108191 | — | — | 1 | 6.22 |
| CHEMBL111076 | ANTHRACENE40 | — | 1 | 6.10 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.10 |
| CHEMBL323158 | — | — | 1 | 6.10 |
| CHEMBL322320 | — | — | 1 | 6.10 |
| CHEMBL111746 | — | — | 1 | 5.80 |
| CHEMBL323489 | — | — | 1 | 5.51 |
| CHEMBL108087 | — | — | 1 | 5.46 |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 1 | 5.22 |
| CHEMBL110097 | — | — | 1 | 5.05 |
| CHEMBL324178 | — | — | 1 | 4.90 |
| CHEMBL322258 | — | — | 1 | 4.70 |
| CHEMBL108041 | — | — | 1 | 4.64 |
| CHEMBL1627157 | — | — | 1 | 4.52 |
| CHEMBL111325 | — | — | 1 | 4.40 |
| CHEMBL324010 | — | — | 1 | 4.30 |
| CHEMBL324905 | — | — | 1 | - |
| CHEMBL418821 | — | — | 1 | - |
| CHEMBL108596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321034 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL321238 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL108992 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL643 | PROMETHAZINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL321238 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL324180 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL321924 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108191 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL111076 | ANTHRACENE40 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL323158 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL322320 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL111746 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL323489 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL108087 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL110097 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL324178 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL322258 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL108041 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1627157 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL111325 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL324010 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL324905 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418821 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL108596 | — | IC50 | = | 1494000.0 | nM | - |