Assay Detail
Functional
CHEMBL762998
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Antimalarial activity against Plasmodium falciparum 3D7
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The effect of fluorine substitution on the antimalarial activity of tebuquine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.56 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339049 | TEBUQUINE | 2.0 | 1 | 7.75 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.70 |
| CHEMBL337981 | FLOUROTEBUQUINE | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339049 | TEBUQUINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL337981 | FLOUROTEBUQUINE | IC50 | = | 58.0 | nM | 7.24 |