Assay Detail
Functional
CHEMBL763015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of methotrexate resistant human T-lymphoblastic leukemia cell subline R30dm
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | R30dm-CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.09 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17383 | — | — | 1 | 6.18 |
| CHEMBL278515 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17383 | — | EC50 | = | 663.0 | nM | 6.18 |
| CHEMBL278515 | — | EC50 | = | 1030.0 | nM | 5.99 |