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Assay Detail

CHEMBL763050

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]rolipram binding to rat brain membranes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Subcellular Membrane
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Phosphodiesterase 4 (CHEMBL2094267)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.
Hersperger R, Bray-French K, Mazzoni L, Müller T.
J Med Chem (2000) 43 : 675 -682
PubMed 10691693 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.40 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL161465 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL161465 IC50 = 4000.0 nM 5.40