Assay Detail
Binding
CHEMBL763082
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In vitro inhibitory activity against human whole cells (CHO) Prostaglandin G/H synthase 2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51434 | — | — | 1 | 8.00 |
| CHEMBL52285 | — | — | 1 | 7.70 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.70 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.52 |
| CHEMBL18264 | — | — | 1 | 7.52 |
| CHEMBL50198 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51434 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL52285 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL18264 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL50198 | — | IC50 | > | 5000.0 | nM | - |