Assay Detail
Binding
CHEMBL763084
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In vitro inhibitory activity against Prostaglandin G/H synthase 2 (COX-2) in human
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of COX-2 selectivity into flurbiprofen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | 8.00 |
| CHEMBL104009 | — | — | 1 | 7.85 |
| CHEMBL317434 | — | — | 1 | 7.68 |
| CHEMBL316771 | — | — | 1 | 7.16 |
| CHEMBL7162 | NS-398 | — | 1 | 7.05 |
| CHEMBL107953 | — | — | 1 | 7.00 |
| CHEMBL325787 | — | — | 1 | 6.82 |
| CHEMBL106828 | — | — | 1 | 6.72 |
| CHEMBL42485 | DUP-697 | — | 1 | 6.72 |
| CHEMBL104592 | — | — | 1 | 6.72 |
| CHEMBL106445 | — | — | 1 | 6.64 |
| CHEMBL104147 | — | — | 1 | 6.50 |
| CHEMBL107938 | — | — | 1 | 6.48 |
| CHEMBL104336 | — | — | 1 | 6.17 |
| CHEMBL432782 | — | — | 1 | 6.14 |
| CHEMBL106203 | — | — | 1 | 5.62 |
| CHEMBL104422 | — | — | 1 | 4.72 |
| CHEMBL108281 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL104009 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL317434 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL316771 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL7162 | NS-398 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL107953 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL325787 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL106828 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL42485 | DUP-697 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL104592 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL106445 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL104147 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL107938 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL104336 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL432782 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL106203 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL104422 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL108281 | — | IC50 | > | 100000.0 | nM | - |