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Assay Detail

CHEMBL763089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against human Prostaglandin G/H synthase 2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2
Penning TD, Kramer SW, Lee LF, Collins PW, Koboldt CM, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC
Bioorg Med Chem Lett (1997) 7 : 2121 -2124
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.85 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302266 1 7.48
CHEMBL67659 1 7.35
CHEMBL66856 1 7.12
CHEMBL274990 SC-58125 1 7.00
CHEMBL68127 1 6.89
CHEMBL65793 1 6.36
CHEMBL67721 1 6.32
CHEMBL67519 1 6.28
CHEMBL302527 1 -
CHEMBL306217 1 -
CHEMBL303891 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302266 IC50 = 33.0 nM 7.48
CHEMBL67659 IC50 = 45.0 nM 7.35
CHEMBL66856 IC50 = 75.0 nM 7.12
CHEMBL274990 SC-58125 IC50 = 100.0 nM 7.00
CHEMBL68127 IC50 = 130.0 nM 6.89
CHEMBL65793 IC50 = 440.0 nM 6.36
CHEMBL67721 IC50 = 480.0 nM 6.32
CHEMBL67519 IC50 = 530.0 nM 6.28
CHEMBL302527 IC50 > 100000.0 nM -
CHEMBL306217 IC50 > 100000.0 nM -
CHEMBL303891 IC50 > 100000.0 nM -