Assay Detail
Binding
CHEMBL763092
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Inhibition of Prostaglandin G/H synthase 2 in human whole blood (HWB) assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.22 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 7.22 |
| CHEMBL296370 | — | — | 1 | 6.85 |
| CHEMBL47294 | — | — | 1 | 6.34 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL49918 | — | — | 1 | 6.30 |
| CHEMBL48671 | — | — | 1 | 6.30 |
| CHEMBL300710 | — | — | 1 | 6.16 |
| CHEMBL49394 | — | — | 1 | 6.10 |
| CHEMBL49319 | — | — | 1 | 6.00 |
| CHEMBL47540 | — | — | 1 | 5.85 |
| CHEMBL45583 | — | — | 1 | 5.85 |
| CHEMBL48073 | — | — | 1 | 5.33 |
| CHEMBL46171 | — | — | 1 | - |
| CHEMBL296220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL296370 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL47294 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL49918 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL48671 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL300710 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL49394 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL49319 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL47540 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL45583 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL48073 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL46171 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL296220 | — | IC50 | < | 400.0 | nM | - |