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Assay Detail

CHEMBL763099

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested for its affinity against HIV-1 protease
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

HIV protease: a novel chemotherapeutic target for AIDS.
Huff JR.
J Med Chem (1991) 34 : 2305 -2314
PubMed 1875332 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.64 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3085527 1 10.52
CHEMBL48565 2 9.70
CHEMBL296115 1 9.52
CHEMBL73875 1 9.11
CHEMBL3350611 1 8.70
CHEMBL307193 1 8.52
CHEMBL77671 1 8.46
CHEMBL3350608 1 8.05
CHEMBL275554 1 7.92
CHEMBL77621 1 7.72
CHEMBL3350613 1 6.85
CHEMBL3350201 1 -
CHEMBL9735 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3085527 IC50 = 0.03 nM 10.52
CHEMBL48565 IC50 = 0.2 nM 9.70
CHEMBL296115 IC50 = 0.3 nM 9.52
CHEMBL73875 IC50 = 0.78 nM 9.11
CHEMBL3350611 IC50 = 2.0 nM 8.70
CHEMBL307193 IC50 = 3.0 nM 8.52
CHEMBL77671 IC50 = 3.5 nM 8.46
CHEMBL3350608 IC50 = 9.0 nM 8.05
CHEMBL275554 IC50 = 12.0 nM 7.92
CHEMBL77621 IC50 = 19.0 nM 7.72
CHEMBL3350613 IC50 = 140.0 nM 6.85
CHEMBL3350201 IC50 < 0.4 nM -
CHEMBL48565 IC50 < 0.4 nM -
CHEMBL9735 IC50 > 10000.0 nM -