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Assay Detail

CHEMBL763102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of HIV-1.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

2',6'-Dimethylphenoxyacetyl: a new achiral high affinity P(3)-P(2) ligand for peptidomimetic-based HIV protease inhibitors.
Beaulieu PL, Anderson PC, Cameron DR, Croteau G, Gorys V, Grand-Maître C, Lamarre D, Liard F, Paris W, Plamondon L, Soucy F, Thibeault D, Wernic D, Yoakim C, Pav S, Tong L.
J Med Chem (2000) 43 : 1094 -1108
PubMed 10737742 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 7.10 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL275969 1 8.82
CHEMBL267571 1 8.80
CHEMBL13011 1 8.77
CHEMBL13217 1 8.74
CHEMBL265588 1 8.59
CHEMBL272599 1 8.15
CHEMBL12900 1 8.08
CHEMBL276431 1 7.92
CHEMBL274128 1 7.70
CHEMBL12449 1 6.92
CHEMBL267553 1 6.68
CHEMBL13205 1 6.58
CHEMBL12413 1 6.40
CHEMBL265333 1 6.38
CHEMBL12705 1 5.96
CHEMBL274291 1 5.85
CHEMBL12906 1 5.62
CHEMBL13075 1 5.60
CHEMBL12886 1 5.38
CHEMBL12161 1 4.96
CHEMBL276892 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL275969 IC50 = 1.5 nM 8.82
CHEMBL267571 IC50 = 1.6 nM 8.80
CHEMBL13011 IC50 = 1.7 nM 8.77
CHEMBL13217 IC50 = 1.8 nM 8.74
CHEMBL265588 IC50 = 2.6 nM 8.59
CHEMBL272599 IC50 = 7.0 nM 8.15
CHEMBL12900 IC50 = 8.4 nM 8.08
CHEMBL276431 IC50 = 12.0 nM 7.92
CHEMBL274128 IC50 = 20.0 nM 7.70
CHEMBL12449 IC50 = 120.0 nM 6.92
CHEMBL267553 IC50 = 210.0 nM 6.68
CHEMBL13205 IC50 = 260.0 nM 6.58
CHEMBL12413 IC50 = 400.0 nM 6.40
CHEMBL265333 IC50 = 420.0 nM 6.38
CHEMBL12705 IC50 = 1100.0 nM 5.96
CHEMBL274291 IC50 = 1400.0 nM 5.85
CHEMBL12906 IC50 = 2400.0 nM 5.62
CHEMBL13075 IC50 = 2500.0 nM 5.60
CHEMBL12886 IC50 = 4200.0 nM 5.38
CHEMBL12161 IC50 = 11000.0 nM 4.96
CHEMBL276892 IC50 > 20000.0 nM -