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Assay Detail

CHEMBL763192

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin E2 receptor EP2 subtype (CHEMBL2488)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design and synthesis of a highly selective EP2-receptor agonist.
Tani K, Naganawa A, Ishida A, Egashira H, Sagawa K, Harada H, Ogawa M, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M.
Bioorg Med Chem Lett (2001) 11 : 2025 -2028
PubMed 11454472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 7.39 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64804 1 8.68
CHEMBL495 ALPROSTADIL 4.0 1 8.59
CHEMBL64246 1 8.55
CHEMBL64483 1 7.96
CHEMBL64663 1 7.50
CHEMBL433249 1 7.41
CHEMBL293242 1 7.37
CHEMBL304225 1 7.35
CHEMBL64423 1 7.27
CHEMBL303763 1 7.15
CHEMBL293697 1 6.89
CHEMBL294585 1 6.66
CHEMBL62885 1 6.24
CHEMBL64358 1 5.85
CHEMBL62987 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64804 EC50 = 2.1 nM 8.68
CHEMBL495 ALPROSTADIL EC50 = 2.6 nM 8.59
CHEMBL64246 EC50 = 2.8 nM 8.55
CHEMBL64483 EC50 = 11.0 nM 7.96
CHEMBL64663 EC50 = 32.0 nM 7.50
CHEMBL433249 EC50 = 39.0 nM 7.41
CHEMBL293242 EC50 = 43.0 nM 7.37
CHEMBL304225 EC50 = 45.0 nM 7.35
CHEMBL64423 EC50 = 54.0 nM 7.27
CHEMBL303763 EC50 = 71.0 nM 7.15
CHEMBL293697 EC50 = 130.0 nM 6.89
CHEMBL294585 EC50 = 220.0 nM 6.66
CHEMBL62885 EC50 = 580.0 nM 6.24
CHEMBL64358 EC50 = 1400.0 nM 5.85
CHEMBL62987 EC50 > 10000.0 nM -