Assay Detail
Binding
CHEMBL763195
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Binding affinity towards human poly(ADP-ribose) polymerase-1 (PARP-1)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.84 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83916 | — | — | 1 | 8.49 |
| CHEMBL81125 | — | — | 1 | 8.35 |
| CHEMBL79218 | — | — | 1 | 8.35 |
| CHEMBL82434 | — | — | 1 | 8.25 |
| CHEMBL83971 | — | — | 1 | 8.23 |
| CHEMBL312135 | — | — | 1 | 8.23 |
| CHEMBL419475 | — | — | 1 | 8.14 |
| CHEMBL81831 | — | — | 1 | 8.06 |
| CHEMBL312719 | — | — | 1 | 8.01 |
| CHEMBL81077 | — | — | 1 | 7.99 |
| CHEMBL84328 | — | — | 1 | 7.93 |
| CHEMBL432166 | — | — | 1 | 7.92 |
| CHEMBL81723 | — | — | 1 | 7.82 |
| CHEMBL443798 | — | — | 1 | 7.51 |
| CHEMBL81143 | — | — | 1 | 6.57 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83916 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL81125 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL79218 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL82434 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL83971 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL312135 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL419475 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL81831 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL312719 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL81077 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL84328 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL432166 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL81723 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL443798 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL81143 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | Ki | = | 3100.0 | nM | 5.51 |