Assay Detail
Binding
CHEMBL763241
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In vitro inhibitory concentration against HIV-1 protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.70 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289195 | — | — | 1 | 9.22 |
| CHEMBL304805 | — | — | 1 | 8.89 |
| CHEMBL70140 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289195 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL304805 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL70140 | — | IC50 | = | 10.0 | nM | 8.00 |