Assay Detail
Functional
CHEMBL763242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV protease
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | hiv |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.73 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419923 | — | — | 1 | 10.00 |
| CHEMBL296115 | — | — | 1 | 9.52 |
| CHEMBL20546 | — | — | 1 | 8.74 |
| CHEMBL21041 | — | — | 1 | 8.72 |
| CHEMBL20930 | — | — | 1 | 7.80 |
| CHEMBL325107 | — | — | 1 | 7.72 |
| CHEMBL2079666 | — | — | 1 | 7.68 |
| CHEMBL279279 | — | — | 1 | 7.66 |
| CHEMBL277034 | — | — | 1 | 6.96 |
| CHEMBL439725 | — | — | 1 | 6.89 |
| CHEMBL2092982 | — | — | 2 | 6.64 |
| CHEMBL422928 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419923 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL296115 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL20546 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL21041 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL20930 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL325107 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2079666 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL279279 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL277034 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL439725 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2092982 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL2092982 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL422928 | — | IC50 | = | 2800.0 | nM | 5.55 |