Assay Detail
Functional
CHEMBL763243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 protease
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.68 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085527 | — | — | 1 | 10.52 |
| CHEMBL3085503 | — | — | 1 | 10.15 |
| CHEMBL47480 | — | — | 1 | 9.82 |
| CHEMBL283583 | — | — | 1 | 9.82 |
| CHEMBL289195 | — | — | 1 | 9.22 |
| CHEMBL282654 | — | — | 1 | 9.15 |
| CHEMBL3143349 | — | — | 1 | 9.00 |
| CHEMBL282041 | — | — | 1 | 8.85 |
| CHEMBL3143353 | — | — | 1 | 8.22 |
| CHEMBL423106 | — | — | 1 | 7.92 |
| CHEMBL249788 | — | — | 1 | 7.92 |
| CHEMBL3143341 | — | — | 1 | 7.70 |
| CHEMBL277034 | — | — | 1 | 6.96 |
| CHEMBL428686 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085527 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3085503 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL47480 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL283583 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL289195 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL282654 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL3143349 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL282041 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3143353 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL423106 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL249788 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3143341 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL277034 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL428686 | — | IC50 | = | 470.0 | nM | 6.33 |