Assay Detail
Functional
CHEMBL763244
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In vitro concentration required to inhibit 50% activity of HIV protease was measured
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | hiv |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.63 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3351098 | — | — | 1 | 8.64 |
| CHEMBL109500 | — | — | 2 | 8.47 |
| CHEMBL3350878 | — | — | 1 | 8.40 |
| CHEMBL432614 | — | — | 1 | 8.05 |
| CHEMBL131802 | — | — | 1 | 7.85 |
| CHEMBL3349889 | — | — | 1 | 7.85 |
| CHEMBL3349554 | — | — | 1 | 7.80 |
| CHEMBL115292 | — | — | 1 | 7.29 |
| CHEMBL113062 | — | — | 1 | 6.35 |
| CHEMBL3349553 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3351098 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL109500 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3350878 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL432614 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL131802 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3349889 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3349554 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL115292 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL109500 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL113062 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3349553 | — | IC50 | = | 850.0 | nM | 6.07 |