Assay Detail
Functional
CHEMBL763256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.03 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298026 | — | — | 1 | 9.10 |
| CHEMBL413509 | — | — | 1 | 8.21 |
| CHEMBL45008 | — | — | 1 | 7.92 |
| CHEMBL444574 | — | — | 1 | 7.89 |
| CHEMBL296715 | — | — | 1 | 7.82 |
| CHEMBL440474 | — | — | 1 | 7.77 |
| CHEMBL297578 | — | — | 1 | 7.40 |
| CHEMBL45418 | — | — | 1 | 7.40 |
| CHEMBL46671 | — | — | 1 | 7.30 |
| CHEMBL42027 | — | — | 1 | 7.25 |
| CHEMBL288978 | — | — | 1 | 7.07 |
| CHEMBL42129 | — | — | 1 | 6.92 |
| CHEMBL291182 | — | — | 1 | 6.89 |
| CHEMBL14359 | — | — | 1 | 6.85 |
| CHEMBL47138 | — | — | 1 | 6.77 |
| CHEMBL280223 | — | — | 1 | 6.75 |
| CHEMBL416262 | — | — | 1 | 6.70 |
| CHEMBL47018 | — | — | 1 | 6.44 |
| CHEMBL46395 | — | — | 1 | 6.34 |
| CHEMBL417171 | — | — | 1 | 6.30 |
| CHEMBL43766 | — | — | 1 | 5.21 |
| CHEMBL416254 | — | — | 1 | 4.38 |
| CHEMBL46743 | — | — | 1 | - |
| CHEMBL45372 | — | — | 1 | - |
| CHEMBL297139 | — | — | 1 | - |
| CHEMBL295623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298026 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL413509 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL45008 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL444574 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL296715 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL440474 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL297578 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL45418 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL46671 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL42027 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL288978 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL42129 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL291182 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL14359 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL47138 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL280223 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL416262 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL47018 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL46395 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL417171 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL43766 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL416254 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL46743 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL45372 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL297139 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL295623 | — | EC50 | > | 100000.0 | nM | - |