Assay Detail
Binding
CHEMBL763259
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Affinity for human Prostanoid FP receptor expressed in COS-7 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.46 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2220404 | CLOPROSTENOL | 2.0 | 1 | 8.70 |
| CHEMBL36041 | — | — | 1 | 8.59 |
| CHEMBL173299 | — | — | 1 | 8.52 |
| CHEMBL815 | DINOPROST | 4.0 | 1 | 8.15 |
| CHEMBL369797 | — | — | 1 | 7.96 |
| CHEMBL425681 | — | — | 1 | 7.92 |
| CHEMBL173680 | — | — | 1 | 7.77 |
| CHEMBL173499 | — | — | 1 | 7.54 |
| CHEMBL176692 | — | — | 1 | 7.20 |
| CHEMBL434173 | — | — | 1 | 7.05 |
| CHEMBL172250 | — | — | 1 | 6.50 |
| CHEMBL36817 | — | — | 1 | 6.46 |
| CHEMBL290969 | — | — | 1 | 6.24 |
| CHEMBL173811 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2220404 | CLOPROSTENOL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL36041 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL173299 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL815 | DINOPROST | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL369797 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL425681 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL173680 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL173499 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL176692 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL434173 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL172250 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL36817 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL290969 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL173811 | — | IC50 | = | 1424.0 | nM | 5.85 |