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Assay Detail

CHEMBL763303

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Binding
Inhibition of HIV-1 protease
ChEMBL ↗
118
Total Activities
118
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Three-dimensional quantitative structure-activity relationship study on cyclic urea derivatives as HIV-1 protease inhibitors: application of comparative molecular field analysis.
Debnath AK.
J Med Chem (1999) 42 : 249 -259
PubMed 9925730 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 118 8.94 10.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85653 — — 1 10.96
CHEMBL313348 — — 1 10.92
CHEMBL405187 — — 1 10.92
CHEMBL291677 — — 1 10.85
CHEMBL313959 — — 1 10.85
CHEMBL408834 — — 1 10.80
CHEMBL315569 — — 1 10.80
CHEMBL316147 — — 1 10.74
CHEMBL262642 — — 1 10.74
CHEMBL315929 — — 1 10.70
CHEMBL262378 — — 1 10.70
CHEMBL313288 — — 1 10.64
CHEMBL11266 — — 1 10.62
CHEMBL89064 — — 1 10.62
CHEMBL86398 — — 1 10.60
CHEMBL57375 — — 1 10.57
CHEMBL85990 — — 1 10.57
CHEMBL431027 — — 1 10.46
CHEMBL313208 — — 1 10.42
CHEMBL311499 — — 1 10.41
CHEMBL81383 — — 1 10.37
CHEMBL313734 — — 1 10.35
CHEMBL313003 — — 1 10.33
CHEMBL316375 — — 1 10.28
CHEMBL86454 — — 1 10.20
CHEMBL89132 — — 1 10.19
CHEMBL82606 — — 1 10.18
CHEMBL438727 — — 1 10.16
CHEMBL313357 — — 1 10.12
CHEMBL315825 — — 1 10.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85653 — Ki = 0.011 nM 10.96
CHEMBL405187 — Ki = 0.012 nM 10.92
CHEMBL313348 — Ki = 0.012 nM 10.92
CHEMBL313959 — Ki = 0.014 nM 10.85
CHEMBL291677 — Ki = 0.014 nM 10.85
CHEMBL315569 — Ki = 0.016 nM 10.80
CHEMBL408834 — Ki = 0.016 nM 10.80
CHEMBL316147 — Ki = 0.018 nM 10.74
CHEMBL262642 — Ki = 0.018 nM 10.74
CHEMBL262378 — Ki = 0.02 nM 10.70
CHEMBL315929 — Ki = 0.02 nM 10.70
CHEMBL313288 — Ki = 0.023 nM 10.64
CHEMBL89064 — Ki = 0.024 nM 10.62
CHEMBL11266 — Ki = 0.024 nM 10.62
CHEMBL86398 — Ki = 0.025 nM 10.60
CHEMBL85990 — Ki = 0.027 nM 10.57
CHEMBL57375 — Ki = 0.027 nM 10.57
CHEMBL431027 — Ki = 0.035 nM 10.46
CHEMBL313208 — Ki = 0.038 nM 10.42
CHEMBL311499 — Ki = 0.039 nM 10.41
CHEMBL81383 — Ki = 0.043 nM 10.37
CHEMBL313734 — Ki = 0.045 nM 10.35
CHEMBL313003 — Ki = 0.047 nM 10.33
CHEMBL316375 — Ki = 0.053 nM 10.28
CHEMBL86454 — Ki = 0.063 nM 10.20
CHEMBL89132 — Ki = 0.064 nM 10.19
CHEMBL82606 — Ki = 0.066 nM 10.18
CHEMBL438727 — Ki = 0.069 nM 10.16
CHEMBL313357 — Ki = 0.075 nM 10.12
CHEMBL315825 — Ki = 0.085 nM 10.07
CHEMBL316407 — Ki = 0.096 nM 10.02
CHEMBL280046 — Ki = 0.11 nM 9.96
CHEMBL314058 — Ki = 0.115 nM 9.94
CHEMBL35860 — Ki = 0.12 nM 9.92
CHEMBL284136 — Ki = 0.12 nM 9.92
CHEMBL285417 — Ki = 0.14 nM 9.85
CHEMBL431017 — Ki = 0.152 nM 9.82
CHEMBL87835 — Ki = 0.18 nM 9.74
CHEMBL275024 — Ki = 0.21 nM 9.68
CHEMBL81396 — Ki = 0.21 nM 9.68
CHEMBL421730 — Ki = 0.245 nM 9.61
CHEMBL85585 — Ki = 0.26 nM 9.59
CHEMBL87329 — Ki = 0.28 nM 9.55
CHEMBL223824 MOZENAVIR Ki = 0.28 nM 9.55
CHEMBL433404 — Ki = 0.29 nM 9.54
CHEMBL33647 — Ki = 0.31 nM 9.51
CHEMBL412810 — Ki = 0.33 nM 9.48
CHEMBL21145 DMP-323 Ki = 0.34 nM 9.47
CHEMBL314008 — Ki = 0.359 nM 9.45
CHEMBL405189 — Ki = 0.41 nM 9.39