Assay Detail
Binding
CHEMBL763307
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Compound was evaluated for in vitro inhibition of human immunodeficiency virus type 1 (HIV-1) Protease
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis-sulfonamide dihydropyrones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.77 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21405 | — | — | 1 | 10.00 |
| CHEMBL22121 | — | — | 1 | 10.00 |
| CHEMBL21188 | — | — | 1 | 9.00 |
| CHEMBL20846 | — | — | 1 | 8.52 |
| CHEMBL20565 | — | — | 1 | 8.33 |
| CHEMBL21281 | — | — | 1 | 8.10 |
| CHEMBL22164 | — | — | 1 | 7.42 |
| CHEMBL2062136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21405 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL22121 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL21188 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL20846 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL20565 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL21281 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL22164 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL2062136 | — | Ki | < | 1.0 | nM | - |