Assay Detail
Binding
CHEMBL763308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human immunodeficiency virus (HIV) protease isolated enzyme assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.93 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427992 | — | — | 1 | 10.80 |
| CHEMBL11266 | — | — | 1 | 10.62 |
| CHEMBL408252 | — | — | 1 | 10.59 |
| CHEMBL427809 | — | — | 1 | 10.46 |
| CHEMBL274213 | — | — | 1 | 10.42 |
| CHEMBL428348 | — | — | 1 | 10.42 |
| CHEMBL406994 | — | — | 1 | 10.34 |
| CHEMBL273927 | — | — | 1 | 10.16 |
| CHEMBL267098 | — | — | 1 | 9.54 |
| CHEMBL416885 | — | — | 1 | 9.52 |
| CHEMBL11180 | — | — | 1 | 9.46 |
| CHEMBL410740 | — | — | 1 | 8.43 |
| CHEMBL269412 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427992 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL11266 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL408252 | — | Ki | = | 0.026 | nM | 10.59 |
| CHEMBL427809 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL274213 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL428348 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL406994 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL273927 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL267098 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL416885 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL11180 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL410740 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL269412 | — | Ki | = | 4.5 | nM | 8.35 |