Assay Detail
Binding
CHEMBL763310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 protease.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.55 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130184 | — | — | 1 | 9.18 |
| CHEMBL128629 | — | — | 1 | 9.14 |
| CHEMBL2062136 | — | — | 1 | 9.10 |
| CHEMBL16636 | — | — | 1 | 9.07 |
| CHEMBL132275 | — | — | 1 | 8.96 |
| CHEMBL131128 | — | — | 1 | 8.72 |
| CHEMBL129802 | — | — | 1 | 8.72 |
| CHEMBL131064 | — | — | 1 | 8.68 |
| CHEMBL127219 | — | — | 1 | 8.64 |
| CHEMBL338756 | — | — | 1 | 8.52 |
| CHEMBL16400 | — | — | 1 | 8.52 |
| CHEMBL279580 | — | — | 1 | 8.52 |
| CHEMBL277309 | — | — | 1 | 8.51 |
| CHEMBL340638 | — | — | 1 | 8.51 |
| CHEMBL131395 | — | — | 1 | 8.39 |
| CHEMBL131658 | — | — | 1 | 8.22 |
| CHEMBL131317 | — | — | 1 | 8.15 |
| CHEMBL16711 | — | — | 1 | 7.96 |
| CHEMBL80882 | — | — | 1 | 7.80 |
| CHEMBL131821 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130184 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL128629 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL2062136 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL16636 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL132275 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL131128 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL129802 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL131064 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL127219 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL338756 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL16400 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL279580 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL277309 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL340638 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL131395 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL131658 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL131317 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL16711 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL80882 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL131821 | — | Ki | = | 19.0 | nM | 7.72 |