Assay Detail
Binding
CHEMBL763318
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Compound was evaluated for the inhibitory activity against HIV-1 protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Application of the three-dimensional structures of protein target molecules in structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.65 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350055 | — | — | 1 | 10.05 |
| CHEMBL73050 | A-77003 | — | 1 | 9.82 |
| CHEMBL3350051 | — | — | 1 | 9.80 |
| CHEMBL43294 | — | — | 1 | 9.74 |
| CHEMBL3350059 | — | — | 1 | 9.72 |
| CHEMBL406493 | A-76928 | — | 1 | 8.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350055 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL73050 | A-77003 | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL3350051 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL43294 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL3350059 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL406493 | A-76928 | Ki | = | 1.66 | nM | 8.78 |