Assay Detail
Binding
CHEMBL763346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.90 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92154 | — | — | 1 | 8.96 |
| CHEMBL91118 | — | — | 1 | 8.92 |
| CHEMBL42485 | DUP-697 | — | 1 | 8.68 |
| CHEMBL92443 | — | — | 1 | 8.66 |
| CHEMBL420987 | — | — | 1 | 8.55 |
| CHEMBL91832 | — | — | 1 | 8.30 |
| CHEMBL90988 | — | — | 1 | 7.92 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.31 |
| CHEMBL330516 | — | — | 1 | 7.21 |
| CHEMBL92485 | — | — | 1 | 7.02 |
| CHEMBL328003 | — | — | 1 | 6.96 |
| CHEMBL328521 | — | — | 1 | 6.28 |
| CHEMBL93803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92154 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL91118 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL42485 | DUP-697 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL92443 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL420987 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL91832 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL90988 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL330516 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL92485 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL328003 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL328521 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL93803 | — | IC50 | > | 5000.0 | nM | - |