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Assay Detail

CHEMBL763348

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PDE4
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphodiesterase 4 (CHEMBL2093863)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

PDE4 inhibitors: new xanthine analogues.
Montana JG, Cooper N, Dyke HJ, Gowers L, Gregory JP, Hellewell PG, Miotla J, Morris K, Naylor R, Tuladhar B, Warneck JB.
Bioorg Med Chem Lett (1998) 8 : 2925 -2930
PubMed 9873649 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.98 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316499 1 5.62
CHEMBL329303 1 5.39
CHEMBL99494 1 5.38
CHEMBL420265 1 5.32
CHEMBL100011 1 5.22
CHEMBL98483 1 5.18
CHEMBL317172 1 5.10
CHEMBL101301 1 4.96
CHEMBL318727 1 4.92
CHEMBL319747 1 4.70
CHEMBL99212 1 4.70
CHEMBL98654 1 4.25
CHEMBL328620 1 4.00
CHEMBL98739 1 -
CHEMBL318705 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316499 IC50 = 2400.0 nM 5.62
CHEMBL329303 IC50 = 4080.0 nM 5.39
CHEMBL99494 IC50 = 4200.0 nM 5.38
CHEMBL420265 IC50 = 4800.0 nM 5.32
CHEMBL100011 IC50 = 6010.0 nM 5.22
CHEMBL98483 IC50 = 6550.0 nM 5.18
CHEMBL317172 IC50 = 7970.0 nM 5.10
CHEMBL101301 IC50 = 11000.0 nM 4.96
CHEMBL318727 IC50 = 11950.0 nM 4.92
CHEMBL319747 IC50 = 20000.0 nM 4.70
CHEMBL99212 IC50 = 20000.0 nM 4.70
CHEMBL98654 IC50 = 56000.0 nM 4.25
CHEMBL328620 IC50 = 100000.0 nM 4.00
CHEMBL98739 IC50 > 20000.0 nM -
CHEMBL318705 IC50 = 110000.0 nM -