Assay Detail
Binding
CHEMBL763349
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Inhibition of rolipram binding
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
PDE4 inhibitors: new xanthine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.67 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329303 | — | — | 1 | 8.05 |
| CHEMBL100011 | — | — | 1 | 7.77 |
| CHEMBL420265 | — | — | 1 | 7.10 |
| CHEMBL316499 | — | — | 1 | 6.66 |
| CHEMBL101301 | — | — | 1 | 6.50 |
| CHEMBL317172 | — | — | 1 | 6.17 |
| CHEMBL99494 | — | — | 1 | 5.99 |
| CHEMBL318727 | — | — | 1 | 5.96 |
| CHEMBL98654 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329303 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL100011 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL420265 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL316499 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL101301 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL317172 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL99494 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL318727 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL98654 | — | IC50 | = | 1600.0 | nM | 5.80 |