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Assay Detail

CHEMBL763366

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prostaglandin E2 receptor EP2 subtype (CHEMBL2488)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design and synthesis of a highly selective EP2-receptor agonist.
Tani K, Naganawa A, Ishida A, Egashira H, Sagawa K, Harada H, Ogawa M, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M.
Bioorg Med Chem Lett (2001) 11 : 2025 -2028
PubMed 11454472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 7.10 8.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64246 1 8.66
CHEMBL64358 1 7.96
CHEMBL433249 1 7.89
CHEMBL293697 1 7.70
CHEMBL64423 1 7.60
CHEMBL64483 1 7.52
CHEMBL64804 1 7.42
CHEMBL304225 1 7.40
CHEMBL303763 1 7.37
CHEMBL64663 1 7.14
CHEMBL495 ALPROSTADIL 4.0 1 7.06
CHEMBL293242 1 7.04
CHEMBL294585 1 6.48
CHEMBL62885 1 6.43
CHEMBL61925 1 5.96
CHEMBL432522 1 5.62
CHEMBL62987 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64246 Ki = 2.2 nM 8.66
CHEMBL64358 Ki = 11.0 nM 7.96
CHEMBL433249 Ki = 13.0 nM 7.89
CHEMBL293697 Ki = 20.0 nM 7.70
CHEMBL64423 Ki = 25.0 nM 7.60
CHEMBL64483 Ki = 30.0 nM 7.52
CHEMBL64804 Ki = 38.0 nM 7.42
CHEMBL304225 Ki = 40.0 nM 7.40
CHEMBL303763 Ki = 43.0 nM 7.37
CHEMBL64663 Ki = 73.0 nM 7.14
CHEMBL495 ALPROSTADIL Ki = 87.0 nM 7.06
CHEMBL293242 Ki = 92.0 nM 7.04
CHEMBL294585 Ki = 330.0 nM 6.48
CHEMBL62885 Ki = 370.0 nM 6.43
CHEMBL61925 Ki = 1100.0 nM 5.96
CHEMBL432522 Ki = 2400.0 nM 5.62
CHEMBL62987 Ki = 3300.0 nM 5.48