Assay Detail
Binding
CHEMBL763371
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Affinity for Prostanoid EP3 receptor expressed in CHO cell line
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.89 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL815 | DINOPROST | 4.0 | 1 | 6.49 |
| CHEMBL2220404 | CLOPROSTENOL | 2.0 | 1 | 6.20 |
| CHEMBL369797 | — | — | 1 | 6.00 |
| CHEMBL36041 | — | — | 1 | 5.51 |
| CHEMBL425681 | — | — | 1 | 5.23 |
| CHEMBL173499 | — | — | 1 | - |
| CHEMBL434173 | — | — | 1 | - |
| CHEMBL290969 | — | — | 1 | - |
| CHEMBL36817 | — | — | 1 | - |
| CHEMBL173811 | — | — | 1 | - |
| CHEMBL173299 | — | — | 1 | - |
| CHEMBL172250 | — | — | 1 | - |
| CHEMBL173680 | — | — | 1 | - |
| CHEMBL176692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL815 | DINOPROST | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL2220404 | CLOPROSTENOL | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL369797 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL36041 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL425681 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL173499 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL434173 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL290969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL36817 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173811 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173299 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL172250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL176692 | — | IC50 | > | 10000.0 | nM | - |