Assay Detail
Binding
CHEMBL763375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-1 protease
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.66 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 8.96 |
| CHEMBL158050 | — | — | 1 | 8.92 |
| CHEMBL161005 | — | — | 1 | 8.92 |
| CHEMBL161393 | — | — | 1 | 8.85 |
| CHEMBL162086 | — | — | 1 | 8.85 |
| CHEMBL350301 | — | — | 1 | 8.82 |
| CHEMBL159580 | — | — | 1 | 8.82 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 8.80 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.68 |
| CHEMBL422718 | — | — | 1 | 8.66 |
| CHEMBL161644 | — | — | 1 | 8.60 |
| CHEMBL18389 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL158050 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL161005 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL161393 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL162086 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL350301 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL159580 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1323 | DARUNAVIR | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL422718 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL161644 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL18389 | — | Ki | = | 87.0 | nM | 7.06 |