Assay Detail
Binding
CHEMBL763376
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Compound was tested for the inhibition of HIV-1 protease by assaying the cleavage of a fluorescent peptide using HPLC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Tricyclic ureas: a new class of HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.43 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290576 | — | — | 1 | 8.44 |
| CHEMBL120610 | — | — | 1 | 8.22 |
| CHEMBL333101 | — | — | 1 | 8.05 |
| CHEMBL120800 | — | — | 1 | 6.12 |
| CHEMBL334312 | — | — | 1 | 5.87 |
| CHEMBL332308 | — | — | 1 | 5.64 |
| CHEMBL332613 | — | — | 1 | 5.62 |
| CHEMBL120521 | — | — | 1 | 5.20 |
| CHEMBL119973 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290576 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL120610 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL333101 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL120800 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL334312 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL332308 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL332613 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL120521 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL119973 | — | Ki | = | 21000.0 | nM | 4.68 |