Assay Detail
Binding
CHEMBL763377
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Inhibition of recombinant HIV-1 protease (NY-5)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.59 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53355 | — | — | 1 | 10.06 |
| CHEMBL299198 | — | — | 1 | 9.72 |
| CHEMBL416131 | — | — | 1 | 9.54 |
| CHEMBL300891 | — | — | 1 | 9.48 |
| CHEMBL52279 | — | — | 1 | 9.13 |
| CHEMBL282457 | — | — | 1 | 8.85 |
| CHEMBL300257 | — | — | 1 | 8.65 |
| CHEMBL443790 | — | — | 1 | 8.32 |
| CHEMBL54191 | — | — | 1 | 8.29 |
| CHEMBL432887 | — | — | 1 | 8.05 |
| CHEMBL54009 | — | — | 1 | 7.66 |
| CHEMBL51258 | — | — | 1 | 7.65 |
| CHEMBL299514 | — | — | 1 | 7.60 |
| CHEMBL53076 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53355 | — | Ki | = | 0.088 | nM | 10.06 |
| CHEMBL299198 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL416131 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL300891 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL52279 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL282457 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL300257 | — | Ki | = | 2.24 | nM | 8.65 |
| CHEMBL443790 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL54191 | — | Ki | = | 5.14 | nM | 8.29 |
| CHEMBL432887 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL54009 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL51258 | — | Ki | = | 22.2 | nM | 7.65 |
| CHEMBL299514 | — | Ki | = | 24.9 | nM | 7.60 |
| CHEMBL53076 | — | Ki | = | 59.0 | nM | 7.23 |