Assay Detail
Binding
CHEMBL763379
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Compound was tested for the inhibitory activity against HIV-protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of delta lactams as nonpeptide HIV-protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.72 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36380 | — | — | 1 | 8.60 |
| CHEMBL39749 | — | — | 1 | 7.82 |
| CHEMBL288239 | — | — | 1 | 7.18 |
| CHEMBL347773 | — | — | 1 | 5.03 |
| CHEMBL149063 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36380 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL39749 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL288239 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL347773 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL149063 | — | Ki | = | 11000.0 | nM | 4.96 |