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Assay Detail

CHEMBL763387

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Binding
Inhibition constant of HIV protease inhibitors
ChEMBL ↗
83
Total Activities
83
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Stereospecific synthesis, structure-activity relationship, and oral bioavailability of tetrahydropyrimidin-2-one HIV protease inhibitors.
De Lucca GV, Liang J, De Lucca I.
J Med Chem (1999) 42 : 135 -152
PubMed 9888839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 83 8.48 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36900 — — 1 11.00
CHEMBL116517 — — 1 10.70
CHEMBL288254 — — 1 10.70
CHEMBL284942 — — 1 10.70
CHEMBL416783 — — 1 10.70
CHEMBL38314 — — 1 10.57
CHEMBL291004 — — 1 10.52
CHEMBL286671 — — 1 10.52
CHEMBL289473 — — 1 10.22
CHEMBL366576 — — 1 10.22
CHEMBL290331 — — 1 10.22
CHEMBL416612 — — 1 10.22
CHEMBL290362 — — 1 10.10
CHEMBL286672 — — 1 10.10
CHEMBL284340 — — 1 10.05
CHEMBL37593 — — 1 10.00
CHEMBL290254 — — 1 10.00
CHEMBL264852 — — 1 10.00
CHEMBL446395 — — 1 10.00
CHEMBL284136 — — 1 9.92
CHEMBL290074 — — 1 9.89
CHEMBL285417 — — 1 9.85
CHEMBL277389 — — 1 9.85
CHEMBL288261 — — 1 9.82
CHEMBL1201230 MAGNESIUM 3.0 1 9.62
CHEMBL286390 — — 1 9.60
CHEMBL36581 — — 1 9.55
CHEMBL223824 MOZENAVIR 2.0 1 9.55
CHEMBL289762 — — 1 9.52
CHEMBL284941 — — 1 9.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36900 — Ki = 0.01 nM 11.00
CHEMBL116517 — Ki = 0.02 nM 10.70
CHEMBL416783 — Ki = 0.02 nM 10.70
CHEMBL288254 — Ki = 0.02 nM 10.70
CHEMBL284942 — Ki = 0.02 nM 10.70
CHEMBL38314 — Ki = 0.027 nM 10.57
CHEMBL291004 — Ki = 0.03 nM 10.52
CHEMBL286671 — Ki = 0.03 nM 10.52
CHEMBL289473 — Ki = 0.06 nM 10.22
CHEMBL416612 — Ki = 0.06 nM 10.22
CHEMBL290331 — Ki = 0.06 nM 10.22
CHEMBL366576 — Ki = 0.06 nM 10.22
CHEMBL290362 — Ki = 0.08 nM 10.10
CHEMBL286672 — Ki = 0.08 nM 10.10
CHEMBL284340 — Ki = 0.09 nM 10.05
CHEMBL37593 — Ki = 0.1 nM 10.00
CHEMBL446395 — Ki = 0.1 nM 10.00
CHEMBL264852 — Ki = 0.1 nM 10.00
CHEMBL290254 — Ki = 0.1 nM 10.00
CHEMBL284136 — Ki = 0.12 nM 9.92
CHEMBL290074 — Ki = 0.13 nM 9.89
CHEMBL285417 — Ki = 0.14 nM 9.85
CHEMBL277389 — Ki = 0.14 nM 9.85
CHEMBL288261 — Ki = 0.15 nM 9.82
CHEMBL1201230 MAGNESIUM Ki = 0.24 nM 9.62
CHEMBL286390 — Ki = 0.25 nM 9.60
CHEMBL223824 MOZENAVIR Ki = 0.28 nM 9.55
CHEMBL36581 — Ki = 0.28 nM 9.55
CHEMBL289762 — Ki = 0.3 nM 9.52
CHEMBL284941 — Ki = 0.31 nM 9.51
CHEMBL36437 — Ki = 0.38 nM 9.42
CHEMBL432093 — Ki = 0.41 nM 9.39
CHEMBL287923 — Ki = 0.48 nM 9.32
CHEMBL285871 — Ki = 0.49 nM 9.31
CHEMBL431321 — Ki = 0.65 nM 9.19
CHEMBL287546 — Ki = 0.87 nM 9.06
CHEMBL286693 — Ki = 0.91 nM 9.04
CHEMBL37472 — Ki = 1.2 nM 8.92
CHEMBL289907 — Ki = 1.4 nM 8.85
CHEMBL416964 — Ki = 1.4 nM 8.85
CHEMBL289393 — Ki = 1.6 nM 8.80
CHEMBL36862 — Ki = 1.7 nM 8.77
CHEMBL36939 — Ki = 2.6 nM 8.59
CHEMBL285282 — Ki = 4.9 nM 8.31
CHEMBL38281 — Ki = 5.6 nM 8.25
CHEMBL286794 — Ki = 6.2 nM 8.21
CHEMBL39592 — Ki = 8.0 nM 8.10
CHEMBL36725 — Ki = 9.8 nM 8.01
CHEMBL38339 — Ki = 11.0 nM 7.96
CHEMBL37033 — Ki = 11.0 nM 7.96