Assay Detail
Binding
CHEMBL763388
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Inhibition constant against HIV-1 Protease
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 52 | 7.93 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127045 | — | — | 1 | 10.05 |
| CHEMBL358924 | — | — | 1 | 10.00 |
| CHEMBL150769 | — | — | 1 | 9.64 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.64 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 9.64 |
| CHEMBL21145 | DMP-323 | — | 1 | 9.57 |
| CHEMBL338428 | — | — | 1 | 9.52 |
| CHEMBL124139 | — | — | 1 | 9.52 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.51 |
| CHEMBL105459 | — | — | 1 | 9.40 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 9.27 |
| CHEMBL340116 | — | — | 1 | 9.26 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.23 |
| CHEMBL264040 | — | — | 1 | 9.22 |
| CHEMBL441167 | — | — | 1 | 9.10 |
| CHEMBL149472 | — | — | 1 | 9.04 |
| CHEMBL127214 | — | — | 1 | 8.92 |
| CHEMBL264815 | — | — | 1 | 8.85 |
| CHEMBL356895 | — | — | 1 | 8.85 |
| CHEMBL150907 | — | — | 1 | 8.68 |
| CHEMBL124093 | — | — | 1 | 8.64 |
| CHEMBL3350189 | — | — | 1 | 8.55 |
| CHEMBL340616 | — | — | 1 | 8.51 |
| CHEMBL357057 | — | — | 1 | 8.00 |
| CHEMBL130998 | — | — | 1 | 7.72 |
| CHEMBL345603 | — | — | 1 | 7.43 |
| CHEMBL149528 | — | — | 1 | 7.40 |
| CHEMBL337872 | — | — | 1 | 7.37 |
| CHEMBL150908 | — | — | 1 | 7.26 |
| CHEMBL133573 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127045 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL358924 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL752 | ADENOSINE PHOSPHATE | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL150769 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL21145 | DMP-323 | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL338428 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL124139 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL105459 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL584 | NELFINAVIR | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL340116 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL264040 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL441167 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL149472 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL127214 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL264815 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL356895 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL150907 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL124093 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3350189 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL340616 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL357057 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL130998 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL345603 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL149528 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL337872 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL150908 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL133573 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL439636 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL357785 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL357812 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL150068 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL130426 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL348185 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL150601 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL356015 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL149863 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL150499 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL345997 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL358219 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL356225 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL347725 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL356211 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL151335 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL150144 | — | Ki | = | - | nM | - |
| CHEMBL150671 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL124065 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL422671 | — | Ki | > | 5000.0 | nM | - |