Assay Detail
Binding
CHEMBL763389
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Inhibition constant against HIV-1 Protease (Remeasured value)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.73 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358008 | — | — | 1 | 10.27 |
| CHEMBL127524 | — | — | 1 | 9.21 |
| CHEMBL150626 | — | — | 1 | 8.25 |
| CHEMBL436262 | — | — | 1 | 8.21 |
| CHEMBL149862 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358008 | — | Ki | = | 0.054 | nM | 10.27 |
| CHEMBL127524 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL150626 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL436262 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL149862 | — | Ki | = | 19.0 | nM | 7.72 |