Assay Detail
Binding
CHEMBL763390
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Inhibition constant was determined against HIV-1 protease
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of gamma-turn mimetics into a model substrate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.50 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115172 | — | — | 2 | 6.37 |
| CHEMBL77621 | — | — | 1 | 4.73 |
| CHEMBL2115173 | — | — | 2 | - |
| CHEMBL2115171 | — | — | 2 | - |
| CHEMBL2115174 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115172 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL2115172 | — | Ki | = | 3890.0 | nM | 5.41 |
| CHEMBL77621 | — | Ki | = | 18800.0 | nM | 4.73 |
| CHEMBL2115173 | — | Ki | = | 372000.0 | nM | - |
| CHEMBL2115171 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL2115174 | — | Ki | = | 1700000.0 | nM | - |
| CHEMBL2115173 | — | Ki | = | 147000.0 | nM | - |
| CHEMBL2115174 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL2115171 | — | Ki | > | 2000000.0 | nM | - |