Assay Detail
Binding
CHEMBL763391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV protease, measured by assaying the cleavage of a fluorescent peptide substrate using HPLC
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 9.83 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305125 | — | — | 1 | 11.00 |
| CHEMBL431174 | — | — | 1 | 10.74 |
| CHEMBL61173 | — | — | 1 | 10.68 |
| CHEMBL38314 | — | — | 1 | 10.57 |
| CHEMBL292858 | — | — | 1 | 10.51 |
| CHEMBL303128 | — | — | 1 | 10.51 |
| CHEMBL60352 | — | — | 1 | 10.46 |
| CHEMBL292631 | — | — | 1 | 10.43 |
| CHEMBL293654 | — | — | 1 | 10.28 |
| CHEMBL304713 | — | — | 1 | 10.28 |
| CHEMBL289473 | — | — | 1 | 10.22 |
| CHEMBL64300 | — | — | 1 | 9.85 |
| CHEMBL434019 | — | — | 1 | 9.80 |
| CHEMBL294582 | — | — | 1 | 9.80 |
| CHEMBL60370 | — | — | 1 | 9.77 |
| CHEMBL444038 | — | — | 1 | 9.77 |
| CHEMBL291621 | — | — | 1 | 9.72 |
| CHEMBL291814 | — | — | 1 | 9.68 |
| CHEMBL292043 | — | — | 1 | 9.59 |
| CHEMBL223824 | MOZENAVIR | 2.0 | 1 | 9.55 |
| CHEMBL294331 | — | — | 1 | 9.36 |
| CHEMBL304491 | — | — | 1 | 9.21 |
| CHEMBL304411 | — | — | 1 | 8.85 |
| CHEMBL304410 | — | — | 1 | 8.44 |
| CHEMBL294295 | — | — | 1 | 8.41 |
| CHEMBL302864 | — | — | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305125 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL431174 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL61173 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL38314 | — | Ki | = | 0.027 | nM | 10.57 |
| CHEMBL292858 | — | Ki | = | 0.031 | nM | 10.51 |
| CHEMBL303128 | — | Ki | = | 0.031 | nM | 10.51 |
| CHEMBL60352 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL292631 | — | Ki | = | 0.037 | nM | 10.43 |
| CHEMBL293654 | — | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL304713 | — | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL289473 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL64300 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL434019 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL294582 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL60370 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL444038 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL291621 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL291814 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL292043 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL223824 | MOZENAVIR | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL294331 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL304491 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL304411 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL304410 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL294295 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL302864 | — | Ki | = | 6.6 | nM | 8.18 |