Assay Detail
Binding
CHEMBL763392
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Inhibition of recombinant HIV-1 protease measured by fluorometric assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.77 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350109 | — | — | 1 | 8.51 |
| CHEMBL150626 | — | — | 1 | 8.47 |
| CHEMBL3350103 | — | — | 1 | 8.14 |
| CHEMBL3350096 | — | — | 1 | 7.96 |
| CHEMBL171148 | — | — | 1 | 7.92 |
| CHEMBL130998 | — | — | 1 | 7.64 |
| CHEMBL3350106 | — | — | 1 | 7.41 |
| CHEMBL3350098 | — | — | 1 | 7.37 |
| CHEMBL3350099 | — | — | 1 | 7.23 |
| CHEMBL3350101 | — | — | 1 | 7.20 |
| CHEMBL3350113 | — | — | 1 | 7.08 |
| CHEMBL3350100 | — | — | 1 | 7.07 |
| CHEMBL3350114 | — | — | 1 | 7.03 |
| CHEMBL3350094 | — | — | 1 | 6.85 |
| CHEMBL3350102 | — | — | 1 | 6.46 |
| CHEMBL3350104 | — | — | 1 | 6.29 |
| CHEMBL3350095 | — | — | 1 | 6.29 |
| CHEMBL3350110 | — | — | 1 | 6.27 |
| CHEMBL3350111 | — | — | 1 | 6.15 |
| CHEMBL3350090 | — | — | 1 | 6.04 |
| CHEMBL3350097 | — | — | 1 | 5.85 |
| CHEMBL3350091 | — | — | 1 | 5.75 |
| CHEMBL3350108 | — | — | 1 | 5.66 |
| CHEMBL3350105 | — | — | 1 | 5.66 |
| CHEMBL3350107 | — | — | 1 | 5.22 |
| CHEMBL3350112 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350109 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL150626 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL3350103 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL3350096 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL171148 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL130998 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3350106 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL3350098 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3350099 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL3350101 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL3350113 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL3350100 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL3350114 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3350094 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3350102 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL3350104 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL3350095 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL3350110 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL3350111 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL3350090 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL3350097 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3350091 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3350108 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3350105 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3350107 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL3350112 | — | Ki | = | 25000.0 | nM | 4.60 |