Assay Detail
Binding
CHEMBL763397
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Inhibitory activity against HIV-1 Protease expressed in Escherichia coli
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of a symmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.52 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340616 | — | — | 1 | 8.51 |
| CHEMBL133517 | — | — | 1 | 8.47 |
| CHEMBL130998 | — | — | 1 | 7.72 |
| CHEMBL337872 | — | — | 1 | 7.37 |
| CHEMBL340986 | — | — | 1 | 7.23 |
| CHEMBL133573 | — | — | 1 | 7.08 |
| CHEMBL130426 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340616 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL133517 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL130998 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL337872 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL340986 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL133573 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL130426 | — | Ki | = | 540.0 | nM | 6.27 |