Assay Detail
Binding
CHEMBL763398
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Inhibitory activity against HIV-1 protease in tandem assay.
37
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 9.01 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332684 | — | — | 1 | 10.74 |
| CHEMBL2111768 | — | — | 2 | 10.49 |
| CHEMBL2092977 | — | — | 1 | 10.40 |
| CHEMBL2112562 | — | — | 1 | 10.22 |
| CHEMBL21405 | — | — | 1 | 10.00 |
| CHEMBL2111769 | — | — | 1 | 10.00 |
| CHEMBL2112566 | — | — | 1 | 9.92 |
| CHEMBL2111770 | — | — | 1 | 9.92 |
| CHEMBL116068 | — | — | 1 | 9.70 |
| CHEMBL2111771 | — | — | 1 | 9.52 |
| CHEMBL324579 | — | — | 1 | 9.28 |
| CHEMBL117638 | — | — | 1 | 9.15 |
| CHEMBL117719 | — | — | 1 | 9.06 |
| CHEMBL116965 | — | — | 1 | 9.00 |
| CHEMBL2092978 | — | — | 1 | 9.00 |
| CHEMBL421230 | — | — | 1 | 8.92 |
| CHEMBL21188 | — | — | 1 | 8.92 |
| CHEMBL332043 | — | — | 1 | 8.77 |
| CHEMBL118006 | — | — | 1 | 8.74 |
| CHEMBL325454 | — | — | 1 | 8.72 |
| CHEMBL119906 | — | — | 1 | 8.64 |
| CHEMBL116265 | — | — | 1 | 8.59 |
| CHEMBL117500 | — | — | 1 | 8.52 |
| CHEMBL116798 | — | — | 1 | 8.52 |
| CHEMBL20846 | — | — | 1 | 8.51 |
| CHEMBL117389 | — | — | 1 | 8.37 |
| CHEMBL326566 | — | — | 1 | 8.21 |
| CHEMBL21281 | — | — | 1 | 8.09 |
| CHEMBL117856 | — | — | 1 | 7.92 |
| CHEMBL324994 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332684 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL2111768 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL2092977 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL2112562 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL21405 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2111769 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2112566 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL2111770 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL116068 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2111768 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL2111771 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL324579 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL117638 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL117719 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL2092978 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL116965 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL421230 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL21188 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL332043 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL118006 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL325454 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL119906 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL116265 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL117500 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL116798 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL20846 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL117389 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL326566 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL21281 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL117856 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL324994 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL115743 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL333924 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL118073 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL222559 | TIPRANAVIR | Ki | = | 0.008 | nM | - |
| CHEMBL117878 | — | Ki | > | 1.0 | nM | - |
| CHEMBL2112565 | — | Ki | = | 0.007 | nM | - |