Assay Detail
Binding
CHEMBL763399
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Inhibitory activity against HIV-1 protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.50 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062136 | — | — | 1 | 9.10 |
| CHEMBL279580 | — | — | 1 | 8.52 |
| CHEMBL16400 | — | — | 1 | 8.52 |
| CHEMBL16526 | — | — | 1 | 8.30 |
| CHEMBL277138 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062136 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL279580 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL16400 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL16526 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL277138 | — | Ki | = | 9.0 | nM | 8.05 |