Assay Detail
Binding
CHEMBL763402
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Inhibitory activity against HIV-1 protease (Escherichia coli)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of novel, potent, diol-based HIV-1 protease inhibitors via intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.39 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325450 | — | — | 1 | 9.40 |
| CHEMBL105459 | — | — | 1 | 9.10 |
| CHEMBL325038 | — | — | 1 | 8.96 |
| CHEMBL325891 | — | — | 1 | 7.55 |
| CHEMBL326386 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325450 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL105459 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL325038 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL325891 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL326386 | — | Ki | = | 112.0 | nM | 6.95 |