Assay Detail
Functional
CHEMBL763417
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In vitro antimalarial activity against Plasmodium falciparum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New semisynthetic quassinoids with in vivo antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.23 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345787 | — | — | 1 | 7.85 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.75 |
| CHEMBL140809 | BRUCEINE B | — | 1 | 7.62 |
| CHEMBL140673 | — | — | 1 | 7.41 |
| CHEMBL154851 | — | — | 1 | 7.28 |
| CHEMBL347315 | — | — | 1 | 7.19 |
| CHEMBL155968 | — | — | 1 | 7.10 |
| CHEMBL157367 | — | — | 1 | 7.05 |
| CHEMBL155758 | — | — | 1 | 7.00 |
| CHEMBL158605 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345787 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL140809 | BRUCEINE B | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL140673 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL154851 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL347315 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL155968 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL157367 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL155758 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL158605 | — | EC50 | = | 880.0 | nM | 6.06 |