Assay Detail
Binding
CHEMBL763422
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Inhibitory concentration against human immunodeficiency virus (HIV) protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.13 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305458 | — | — | 1 | 8.40 |
| CHEMBL74166 | — | — | 1 | 8.22 |
| CHEMBL70388 | — | — | 1 | 8.15 |
| CHEMBL302958 | — | — | 1 | 8.00 |
| CHEMBL72129 | — | — | 1 | 7.89 |
| CHEMBL71961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305458 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL74166 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL70388 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL302958 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL72129 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL71961 | — | IC50 | 10.0 | nM | - |