Assay Detail
Binding
CHEMBL763477
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Inhibition of calmodulin dependent phosphodiesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.19 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345671 | — | — | 1 | 4.19 |
| CHEMBL423054 | — | — | 1 | - |
| CHEMBL422519 | — | — | 1 | - |
| CHEMBL158848 | — | — | 1 | - |
| CHEMBL156809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345671 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL423054 | — | IC50 | = | 313000.0 | nM | - |
| CHEMBL422519 | — | IC50 | = | 584000.0 | nM | - |
| CHEMBL158848 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL156809 | — | IC50 | > | 1500000.0 | nM | - |