Assay Detail
Functional
CHEMBL763539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro anti-protozoal activity against Plasmodium falciparum Ghana
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives with in vitro activity against Plasmodium falciparum, Trypanasoma b brucei, Trypanasoma cruzi, and Leishmaniasis infantum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.97 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 7.60 |
| CHEMBL60144 | — | — | 1 | 7.00 |
| CHEMBL59755 | — | — | 1 | 6.00 |
| CHEMBL60487 | — | — | 1 | 5.30 |
| CHEMBL60505 | — | — | 1 | 5.22 |
| CHEMBL60085 | — | — | 1 | 4.72 |
| CHEMBL61588 | — | — | 1 | - |
| CHEMBL60093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566534 | ARTEMETHER | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL60144 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL59755 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL60487 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL60505 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL60085 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL61588 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL60093 | — | IC50 | > | 32000.0 | nM | - |