Assay Detail
Functional
CHEMBL763564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.69 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278590 | GSK-9578 | — | 1 | 7.30 |
| CHEMBL125230 | — | — | 1 | 6.82 |
| CHEMBL340011 | — | — | 1 | 6.39 |
| CHEMBL124842 | — | — | 1 | 6.10 |
| CHEMBL124079 | — | — | 1 | 5.85 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | 4.52 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.30 |
| CHEMBL683 | CLOFIBRIC ACID | 2.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278590 | GSK-9578 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL125230 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL340011 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL124842 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL124079 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL683 | CLOFIBRIC ACID | EC50 | = | 55000.0 | nM | 4.26 |