Assay Detail
Binding
CHEMBL763565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Analysis of the critical structural determinant(s) of species-selective peroxisome proliferator-activated receptor alpha (PPAR alpha)-activation by phenylpropanoic acid-type PPAR alpha agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.84 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318351 | — | — | 1 | 9.21 |
| CHEMBL107789 | — | — | 1 | 7.09 |
| CHEMBL120748 | — | — | 1 | 5.57 |
| CHEMBL322086 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318351 | — | EC50 | = | 0.615 | nM | 9.21 |
| CHEMBL107789 | — | EC50 | = | 80.3 | nM | 7.09 |
| CHEMBL120748 | — | EC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL322086 | — | EC50 | = | 3380.0 | nM | 5.47 |